Modulen Ibd Latte Polvere 400g

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The new Gut Friendly Recipes a free, online, recipe finder with more than 500 easy recipes for gut-friendly and nutritious meals, helps to answer that question. The easy-to-navigate recipe finder was launched on January 31, 2023 by the Crohn’s & Colitis Foundation and Nestlé Health Science. We’re thrilled to partner with Nestlé Health Science to launch Gut Friendly Recipes, a comprehensive free digital tool that will make preparing tasty and gut-healthy meals easier than ever before,” said Michael Osso, President and Chief Executive Officer of the Crohn’s & Colitis Foundation. “People dealing with IBD or other chronic gut issues often have to carefully consider what they can or cannot eat. As the nation’s leading organization dedicated to advancing IBD research and improving patient quality of life, we know that our patient community will absolutely benefit from the delicious and dietitian-approved healthy meal options on Gut Friendly Recipes. We also hope that this recipe finder will be a trusted, easy-to-use tool for not only IBD patients, physicians, and nutritionists, but for everyone with an interest in gut-friendly eating.” > As directed by a Healthcare Professional1 kcal/ml: 50 g powder (6 scoops) + 210 ml water = 250 ml 1.5 kcal/ml: 75 g powder (9 scoops) + 190 ml = 250 ml1 kcal/ml: 200 g powder (24 scoops) + 850 ml water = 1000 ml 1.5 kcal/ml: 300 g powder (36 scoops) + 750 ml = 1000 ml Even though studies are contradicting each other about Modulen ® efficiency on disease location [ 3, 4, 10], numerous clinicians noticed that at least one ileal damage is requested. The pathophysiological differences may explain this outcome. For instance, NOD2 mutations are associated with CD with at least one lesion located in the small intestine. In view of its numerous intestinal functions, this receptor can play a significant role in EN mechanisms after microbiota recognition. This suggests that the possible modification of the intestinal microbiota by Modulen ® could be primordial to induce remission. Additional studies on intestinal consequent microbiota are encouraged, both in terms of taxonomy and time. Albeit the outcome could suggest enhancing the dietary therapy with prebiotics or probiotics, one should note that the contrary could appear if the ensuing microbiota variations are highly specific. Nestlé Health Science, a leader in the science of nutrition, is a globally managed business unit of Nestlé. We are committed to redefining the management of health, offering an extensive portfolio of science-based consumer health, medical nutrition, pharmaceutical therapies, and vitamin and supplement brands. Our extensive research network provides the foundation for products that empower healthier lives through nutrition. Headquartered in Switzerland, we have more than 12,000 employees around the world, with products available in more than 140 countries.

Gut Friendly Recipes offers dietitian-approved recipes for people with digestive issues, Inflammatory Bowel Disease (IBD) patients, and for general nutritious eating B6, B1, A, B2, folic acid, K, biotin, D, B12) and choline bitartrate. MODULEN® (400 g powder) Nutrition Information Serve size: 50 g (made up volume 250 ml) Serves per container: 8Nutrient Units Per serve Per 100 mlEnergy kJ / kcal 1037 / 250 415 / 100Protein (14% kcal) g 9.0 3.6Carbohydrate (44% kcal) of which: g 27 10.8- Sugars g 10.5 4.2Fat (42% kcal) of which: g 11.5 4.6- Saturated g 6.6 2.6- Monounsaturated fatty acids g 2.0 0.78- Polyunsaturated fatty acids g 1.2 0.48- MCT g 3.0 1.2Fibre (0% kcal) g 0 0Sodium mg 85 34VitaminsBiotin μg 8.0 3.2Folic acid μg 60 24Niacin mg 2.9 1.2mg NE 4.9 2.0Pantothenic acid mg 1.2 0.48Vitamin A μg 210 84Vitamin B1 mg 0.29 0.12Vitamin B2 mg 0.32 0.13Vitamin B6 mg 0.41 0.16Vitamin B12 μg 0.80 0.32Vitamin C mg 23 9.2Vitamin D μg 2.5 1.0Vitamin E mg TE 3.3 1.3Vitamin K μg 13 5.2MineralsCalcium mg 222 89Chloride mg 182 73Chromium μg 12 4.8Copper mg 0.24 0.10Iodine μg 24 10Iron mg 2.7 1.1Magnesium mg 50 20Manganese mg 0.49 0.20Molybdenum μg 18 7.2Phosphorus mg 150 60Potassium mg 300 120Selenium μg 8.5 3.4Zinc mg 2.3 0.92Other NutrientsCholine mg 17 6.8 Modulen (400g powder) The inflammatory status of patients was evaluated in parallel. The clinical studies demonstrate that symptoms decrease along with inflammatory serum markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels [ 1, 2, 4, 7, 9], platelets [ 1, 4], fibrinogen [ 7], and TNFα levels [ 2] ( Table 1). Among the studies already mentioned, three of them reported a significant increase in albumin levels. Furthermore, these serological results were accompanied by reduced inflammation at the mucosal level. Ileal biopsies from CD patients pre- and post-EEN revealed a decrease of IL-1β and IFN-γ mRNA, whereas colonic ones only presented IL-1β and CXCL-8 mRNA reduction [ 2, 37]. These results attest to the anti-inflammatory effects of Modulen ®. Contains Transforming Growth Factor –ß2 (TGF-ß2) from patented manufacturing process. TGF-ß2 has natural anti-inflammatory properties to reduce inflammation associated with inflammatory bowel disease

MODULEN IBD - Crohn's Liquid Diet 

To date, while the majority of medical treatments target the immune cell compartment of the intestinal mucosa to attenuate inflammation, Modulen ® EEN leads to significant clinical remission, but also to significant mucosal healing, the most significant remission parameter by far, targeting the intestinal barrier. The fact that this formula can be orally administrated due to its palatability confers a greater tolerance and compliance for CD patients. The more compliant the patient is, the greater the remission is [ 4]. Compliance can be affected by different factors, such as age, gender, and even beliefs [ 61]. To facilitate EN, allowing a regular diet is an alternative. Even if it seems to not revoke the benefits of Modulen ®, additionally, regular diet can depend on personal education, beliefs, habits, and temptations, and then influence in somehow the outcome. Therefore, regulated partial nutrition could be a preferable approach to a free diet to control efficacy over time [ 8]. Few studies aimed to assess the effectiveness of Modulen ® in the maintenance phase of CD. Modulen ® represented around 40% of daily caloric intake [ 11, 12, 13]. Another approach could be to perform cycles of Modulen ®, 2 weeks of EEN every 8 weeks, rather than daily use; the recruitment of this protocol was completed, but the data are not published yet (ClinicalTrials.gov, {"type":"clinical-trial","attrs":{"text":"NCT02201693","term_id":"NCT02201693"}}NCT02201693). Other than intestinal symptoms, CD can lead to extra-intestinal ones such as bone, skin, ocular, and thromboembolic complications. These events were not investigated after EN and more specifically Modulen ® therapy. This goes along with other organ consequences. The most alarming repercussion is steatosis as non-alcoholic fatty liver disease is common in IBD. Considering TGF-β2 content, and the risk of hepatic fibrosis, hepatologists could avoid Modulen ® therapy for CD patients.

The platform which uses a machine-learning algorithm and nutrition data to generate personalized meal plans, was developed by Nestlé Research using its expertise in digital health and nutritional science. The recipe selection and educational components are managed by the Foundation. A new study has found that the Crohn’s Disease Exclusion Diet (CDED), a novel whole-food based dietary approach, combined with Modulen IBD, a Nestlé Health Science nutritional supplement for partial enteral nutrition (PEN), is effective for the management of Crohn’s disease. Modulen ® effectiveness to induce remission has been shown in many studies ( Table 1). These studies have several limitations, while they are mainly retrospective or with no randomized control, and the endpoints were clinical remission rather than mucosal healing. Among patients treated exclusively with Modulen ®, 65% of patients (19/27 children) have displayed a PCDAI ≤ 15 after 6–8 weeks [ 1] and 79% (23/29 children) have reached clinical remission with a PCDAI ≤ 10 after 8 weeks of CT32I Nestlé ® formula treatment [ 2]. A similar rate (80%) has been described by Buchanan et al. (105/114 children), who have combined both oral and nasogastric administration [ 3]. The mode of administration depends on patients’ clinical status [ 33], but does not affect the clinical remission rate. After eight weeks of exclusive Modulen ®, oral and nasogastric administration induces 75% and 85% of clinical remission respectively (PCDAI < 10), without any statistical difference between treatments ( Table 2) [ 4]. Considering the severe corticosteroid side effects, numerous studies have already illustrated that exclusive nutrition has an equal efficiency to corticosteroids in children contrary in adults [ 34]. To our knowledge, only two studies comparing corticosteroids to exclusive nutrition have been performed by adopting the current Modulen ® formula [ 5, 6]. In the first one [ 5], an exclusive 10-week diet induced clinical remission and the PCDAI reduction was similar to corticosteroid treatment. However, endoscopic and histological healing was achieved at 73% in the polymeric diet group (14/19 children), significantly higher compared to 40% in the corticosteroid group (6/15). In the second one [ 6], PCDAI significantly decreased after eight weeks of polymeric diet compared to corticosteroids, from the second week until the third. In a long-term follow-up on mesalamine maintenance, the remission rate was longer when the induction treatment was performed by the polymeric diet, as more than 80% of individuals were in remission one year after. Another study has compared corticosteroids, cyclosporine A and enteral nutrition (EN) with an elemental diet (Flexical, Mead Johnson) or a polymeric diet (Nestlé) ( Table 1) [ 35]. After 8 weeks of treatments, among the three patients treated with the polymeric diet, two of them had an improved histological inflammation. This outcome was similar to the elemental diet (5/6) and cyclosporine A (6/9), while it did not improve on prednisolone (1/10). However, the number of TNFα secreting cells only decreased on cyclosporine A. Modulen® IBD is a nutritionally complete formula suitable for oral and tube feeding, especially designed for the dietary management of Crohn’s Disease in paediatric (>5years) and adult patients.Mechanisms of action of Modulen ® on intestinal epithelium. The left panel represents the consequences of a liquid, exclusive, and fibers/lactose/gluten-free diet, as well as TGF(transforming growth factor-beta) MCT (medium-chain triglycerides), palmitic acid, α-linolenic acid, and 15-HETE (15-hydroxyeicosatetraenoic acid);. The right panel focuses on leucine, caprylic, glutamic and palmitic acid, MCT, TGF-β, and β-casofensin. Modulen ® is different from other EN formulas mainly by its TGF-β2 amount ( Figure 1 right panel) [ 32]. This cytokine has intestinal benefits such as promoting IgA production, regulating tight junction proteins, and preventing Goblet cell depletion [ 41]. Furthermore, stimulating intestinal cells with TGF-β2 has down-regulated CXCL-8, IL-6, and TNFα ( Figure 1, right panel) [ 42]. This lessening concerns both macrophage cytokines [ 42] and transcriptional level modifications [ 42, 43]. Moreover, depleting TGF-β signalling emphasizes weight loss and inflammation in a mouse model of colitis [ 43]. Other studies have shown the ability of TGF-β2 to prevent necrotizing enterocolitis [ 44] and mucositis [ 45]. Knowing that TGF-β is also involved during restitution of mucosal healing [ 41], remission outcomes obtained with Modulen ® could be principally explained by this cytokine ( Figure 1, right panel). However, other components may play a potential role and should not be excluded. This is the case of protein and fatty acid contents that deserve interest. What can I eat?” That’s the number one question that people with chronic digestive issues ask the Crohn’s & Colitis Foundation in the U.S.A.

for use in Crohn’s disease either as an alternative to steroid therapy during the active phase, as a supplement during the remission phase or adjunct to medical steroid therapy. Finally, in addition to gut integrity, Modulen ® elements will likely benefit other organs and physiological processes allowing a well-being stage. Naturally, physical ameliorations go along with mental ones, thus achieving an effective quality of life.

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There is no cure for Crohn’s disease- a chronic condition that causes inflammation of the digestive system or gut. Most patients typically rely on anti-inflammatory drugs and surgical interventions to manage their symptoms, which can be expensive, for both the patient and health care providers. However, a randomized control trial, has shown that a nutrition-based approach, combining CDED and Modulen IBD is effective for the management and remission of Crohn’s disease.