SANPROBI IBS, CAPSULES results in a reduction of abdominal pain, bloating, and normalization of bowel movements 20 PCS.

Product Information

Rahman T., Hosen I., Islam M.M.T., Shekhar H.U. Oxidative stress, and human health. Adv. Biosci. Biotechnol. 2012;3:997–1019. doi: 10.4236/abb.2012.327123. The intervention factor was the SANPROBI BARRIER multi-strain probiotic (commonly available in pharmacies) or placebo (created on the model of a probiotic capsule, specially for the needs of research, by Sanprobi Sp. z o.o.). You may also open the capsule and sprinkle the probiotic into a cold drink or cold soft food, following the same directions for the oral powder.

Patients will fill out questionnaires regarding the gastrointestinal symptoms associated with metformin at a dose they did not tolerate and at a time of reduced daily dose of metformin they do tolerate (patients are accepted to have gastrointestinal symptoms which they accept). Fedewa MV, Hathaway ED, Ward-Ritacco CL. Effect of exercise training on C reactive protein: a systematic review and meta-analysis of randomised and non-randomised controlled trials. Br J Sports Med. 2017 Apr;51(8):670-676. doi: 10.1136/bjsports-2016-095999. Epub 2016 Jul 21.

Drug Interventions

This incredibly advanced functional system created by the mucous membrane of enterocytes and microorganisms that live there is unfortunately extremely susceptible to damages. The largest devastation in the natural bacterial microflora is made by antibiotics, still very willingly prescribed by doctors. Importantly, they cause changes in the bacterial composition of the digestive system not only during their application, but they also have influence on the probiotic barrier for many years after antibiotic therapy. To the best of our knowledge, this will be the first intervention study assessing the efficacy of both probiotic supplementation and a gluten-free diet and comparing the effect of both interventions and their combination in MDD patients. The protocol and the outline were developed by a multidisciplinary researcher team. The methodology employed in the study benefited greatly from our diverse set of knowledge, experience and perspectives. Considering the highly rigoristic selection criteria, the participant group is relatively large. Rigorous procedures established for this trial will be followed by well-trained researchers to ensure that research will be conducted in accordance with standards of best practice. The measurements listed above will be introduced to reduce the potential bias related to confounding variables (e.g. smoking, physical activity, and diet).

Statistical analysis will be performed according to the E9 Statistical Principles for Clinical Trials [ 80]. For quantitative outcomes, the between-group comparisons will be performed using the ANOVA or Kruskal-Wallis rank-based nonparametric test depending on the data distribution followed by appropriate post-hoc tests. The qualitative outcomes will be compared using the Chi-square test. Longitudinal data will be analyzed with either repeated measures of ANOVA or aligned rank-transform ANOVA, depending on the data distribution, or McNemar’s test. Content of components in one capsule: Bifidobacterium lactis W52, W63 Lactobacillus brevis, Lactobacillus casei W56, W19 Lactococcus lactis, Lactococcus lactis W58, W37 Lactobacillus acidophilus, Bifidobacterium bifidum W23, W24 Lactobacillus salivarius. Metformin intolerant patients have been defined as those not able to be treated with the metformin daily dose exceeding 1500 mg due to gastrointestinal upset. Sposób użycia: Dzieci od 3 do 12 roku życia: 1–2 kapsułki dziennie. Dorośli i dzieci powyżej 12 roku życia: 2–4 kapsułki dziennie. Damage to the intestinal barrier may occur in the course of diseases such as: food allergies, celiac disease, inflammatory bowel disease, autoimmune diseases, and chronic liver diseases. Additional factors causing barrier disruption may be: inadequate diet, alcohol, stress, abuse of medications, e.g. painkillers and antibiotics, gastrointestinal and upper respiratory tract infections, as well as radio and chemotherapyHuang WC, Wei CC, Huang CC, Chen WL, Huang HY. The Beneficial Effects of Lactobacillus plantarum PS128 on High-Intensity, Exercise-Induced Oxidative Stress, Inflammation, and Performance in Triathletes. Nutrients. 2019 Feb 7;11(2):353. doi: 10.3390/nu11020353. Visit 7 - month 5 (4 weeks ± 3 days from the visit 6) Gastrointestinal symptoms questionnaire administration. This is why the investigators hypothesize that it may also reduce the intensity of adverse effects associated with metformin use.