Imodium Instants - Fast Dissolving Tablets for On-The-Go Diarrhoea Relief in Under 1 Hour, 6 Count (Pack of 1)

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Cardiac events including QT interval and QRS complex prolongation and torsades de pointes have been reported in association with overdose. Some cases had a fatal outcome (see section 4.9). Overdose can unmask existing Brugada syndrome. Patients should not exceed the recommended dose and/or the recommended duration of treatment. If you notice any of the above, stop using the medicine and talk to a doctor. Other effects that may occur The orodispersible tablet should be placed on the tongue. The tablet will dissolve and is to be swallowed with saliva. No liquid intake is needed for the orodispersible tablet. Tablets that melt in your mouth: put the tablet on your tongue and let it melt in your saliva. You can then swallow it without a drink. Do not chew it. Now read this whole leaflet carefully before you use this medicine.Keep the leaflet: you might need it again. 1 What the medicine is for

This medicine contains less than 0.00003 mg of alcohol (ethanol) in each tablet. The small amount of alcohol in this Distribution: Studies on distribution in rats show a high affinity for the gut wall with a preference for binding to receptors of the longitudinal muscle layer. The plasma protein binding of loperamide is 95%, mainly to albumin. Non-clinical data have shown that loperamide is a P-glycoprotein substrate. This medicine contains 0.00066 mg benzyl alcohol in each dose (2 mg) which is equivalent to 0.00033 mg/mg. Benzyl alcohol may cause allergic reactions. Ask your doctor or pharmacist for advice if you have liver or kidney disease, or if pregnant or breast feeding. This is because large amounts of benzyl alcohol can buildup in your body and may cause side effects (called “metabolic acidosis”). For adults and young people aged 18 and over who have been diagnosed with IBS (Irritable Bowel Syndrome).If any of the following now apply, do not use the product without first consulting your doctor, even if you know you have IBS: Your body can lose large amounts of fluids and salts when you have diarrhoea. You need to replace the fluid by drinking more liquid than usual. Ask your pharmacist about rehydration therapy to replace lost salts. Caution is needed in patients with a history of drug abuse. Abuse and misuse of loperamide, has been described (see section 4.9). Loperamide is an opioid with low bioavailability and limited potential to penetrate the blood brain barrier at therapeutic doses. However, addiction is observed with opioids as a class. If any of these applies to you (now or in the past), talk to a doctor or pharmacist. Pregnancy or breast-feeding

You can buy loperamide from pharmacies and supermarkets. It is also available on prescription for treating some bowel conditions.

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Loperamide is also available combined with simeticone. Simeticone is used to treat farting (flatulence or wind). Taking these medicines together helps if you have diarrhoea with painful stomach cramps and bloating.

Metabolism: loperamide is almost completely extracted by the liver, where it is predominantly metabolized, conjugated and excreted via the bile. Oxidative N-demethylation is the main metabolic pathway for loperamide, and is mediated mainly through CYP3A4 and CYP2C8. Due to this very high first pass effect, plasma concentrations of unchanged drug remain extremely low. Imodium Instant Melts contains benzyl alcohol, which may cause allergic reactions. Imodium Instants must be used with caution in patients with renal or hepatic impairment, or in patients who are pregnant or breast-feeding, because of the risk of accumulation and toxicity (metabolic acidosis). headaches – make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller. Talk to your doctor if the headaches last longer than a week or are severe. You can also report side effects directly via the Yellow Card Scheme at: or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.Bullous eruption a (including Stevens-Johnson syndrome, Toxic epidermal necrolysis and Erythema multiforme) feeling dizzy – if loperamide makes you feel dizzy when you stand up, try getting up very slowly or stay sitting down until you feel better. If you begin to feel dizzy, lie down so that you do not faint, then sit until you feel better. Avoid driving, cycling, or using tools or machines if you feel dizzy. Loss of consciousness or reduced level of consciousness (passing out, feeling faint or less alert), uncoordinated movements.

The tablets contain loperamide hydrochloride, a substance that helps reduce diarrhoea by slowing down an overactive bowel. This allows water and salts that are usually lost in diarrhoea to be absorbed by the body. If your doctor has prescribed loperamide for you or your child, follow their instructions about how and when to take it. How to take itIf your doctor prescribes loperamide for long-lasting diarrhoea, they will tell you how much to take. The usual starting dose is: In individuals who have ingested overdoses of loperamide, cardiac events such as QT interval and QRS complex prolongation, torsades de pointes, other serious ventricular arrhythmias, cardiac arrest and syncope have been observed (see section 4.4). Fatal cases have also been reported. Overdose can unmask existing Brugada syndrome. Allergic reactions including unexplained wheezing, shortness of breath, passing out or swelling of face and throat. The concomitant administration of loperamide (4 mg single dose) and itraconazole, an inhibitor of CYP3A4 and P-glycoprotein, resulted in a 3 to 4-fold increase in loperamide plasma concentrations. In the same study a CYP2C8 inhibitor, gemfibrozil, increased loperamide by approximately 2-fold. The combination of itraconazole and gemfibrozil resulted in a 4-fold increase in peak plasma levels of loperamide and a 13-fold increase in total plasma exposure. These increases were not associated with central nervous system (CNS) effects as measured by psychomotor tests (i.e. subjective drowsiness and the Digit Symbol Substitution Test). see section 3). Serious heart problems (symptoms of which include fast or irregular heartbeat) have been reported in patients who have taken too much loperamide, the active ingredient in IMODIUM® Instant Melts.