PRO PLAN Neurocare Adult Dry Dog Food 12kg, Pack of 1

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More recently, a diet based on inclusion of MCTs was evaluated in epileptic dogs. 27 Although the exact mechanism of action of MCTs is not fully known, proposed mechanisms include provision of an alternative energy supply to the brain (energy metabolism is insufficient in epileptic dogs), global changes in lipid metabolism and effects on cerebral neurotransmitters. 28–32 The randomised, placebo-controlled, double-blinded, crossover study revealed that most dogs fed the test diet (containing MCT oil) for 90 days showed a reduction in seizure frequency. 27 In this study, 71 per cent of dogs experienced reduced seizure frequency, with 48 per cent having a ≥50 per cent reduction in seizure frequency and 14 per cent of dogs achieving complete seizure freedom. The positive effect of an MCT-enriched diet was also highlighted in a recent study comparing an MCT oil dietary supplement to a control oil (olive oil) in 28 dogs with IE being treated with standard ASD(s). 33 Overall seizure and seizure-day frequency were significantly lower in dogs that had the MCT oil dietary supplement added to their routine diet compared to dogs that had the control oil added to their food. Similar to the study by Law and others, 2015, 71 per cent of dogs improved, and 18 per cent had more than 50 per cent reduction in seizure frequency, although only 8 per cent became seizure free. 33 TH, Davies ES, Pan Y, et al. A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy. Br J Nutr. 2015;114:1438-47. Research 1from RVC canine epilepsy clinic, in partnership with Nestlé Purina, provided the basis for the development of the first and only diet to help nutritionally manage dogs with idiopathic epilepsy as an adjunct to veterinary therapy.

By participating in this promotion, participants are deemed to have accepted these terms and conditions. If any of these clauses should be determined to be illegal, invalid, or otherwise unenforceable then it shall be severed and deleted from these Terms and Conditions and the remaining clauses shall survive and remain in full force and effect. One of the most exciting new areas of research in canine epilepsy is on the effects of diet. Holger added: “Breeders and dog owners have often told me that they feel that the food that they give to their dogs does influence the control of their seizures.” Professor Holger Volk leads dog epilepsy research Support your dog's brain function with this clinically proven dry dog food specially developed with medium chain triglycerides and neurosupportive nutrients in a ketogenic recipe.This Purina Pro Plan NC Neurocare complete dry food has been specially developed for adult and senior dogs, with medium chain triglycerides (MCTs) and a special combination of nutrients to help support healthy brain function. The offer is available for PURINA PRO PLAN® CAT and DOG FOODS AND SUPPLEMENTS RANGES as listed above and does not apply to any other product.By entering the Promotion, entrants confirm that they have read and agree to be bound by these Terms and Conditions and by the decisions of the Promoter. Purina Pro Plan Veterinary Diets NC NeuroCare Canine Formula is formulated to meet the nutritional levels established by the AAFCO Dog Food Nutrient Profiles for growth of puppies and maintenance of adult dogs.

To expand the veterinary management options for canine patients with ASD treated IE, a commercially available diet enriched with 6.5 per cent MCT oil (as fed basis) plus a blend of other nutrients was offered to pet owners as an open-label feeding trial to prospectively evaluate seizure outcomes resulting from dietary management as an adjunct to ASD treatment. This study builds on existing canine research that demonstrated the clinical efficacy of a diet enriched with MCT oil in two double-blinded, placebo-controlled, prospective diet clinical trial with a population of ASD(s)-resistant IE dogs. 27,33 In the study by Law and others, the diet contained 5.5 per cent MCT oil (as fed basis) compared with 6.5 per cent added MCT oil in this current study. Previous unpublished work from Nestlé Purina revealed that ketone production is dose-dependently increased with MCT inclusion. However practically, the inclusion level of 9 per cent MCT oil (as fed basis) to a diet has limitations because of reduced palatability observations, as demonstrated in a study of the benefits of an MCT oil-enriched food fed to dogs with canine cognitive dysfunction syndrome. 47Regarding the ataxia level, three owners reported mild ataxia (1/10 or 3/10) at day 0, two of which improved during the study (ataxia level of 0/10 or 1/10 at day 84, respectively). One dog remained unchanged over the trial (3/10). Sedation was reported in 6 out of 21 dogs at day 0. Two dogs had a sedation level of 5/10, four had a level of ≤2/10. At the end of the study (day 84), three dogs decreased the level of sedation, and three remained in the same level. This study differed in several distinguishing aspects from the former aforementioned studies and does have some additional limitations worth noting. The first notable distinguishing factor is that multiple first-opinion veterinary clinics participated in the recruitment and management of the patients that spanned over five different countries across Europe, whereas the other study 27 was performed in a single referral hospital setting and conducted entirely through the Royal Veterinary College Clinical Investigation Center referral hospital in the UK. Secondly, the level of MCT oil (6.5 per cent) differed relative to other studies referenced above. Thirdly, the recruited pet population was focused on a less severe type of IE with tier 1 diagnosis. And finally, to obtain clinically relevant data acquired by collaborating vets and their clients, the data represent a compilation of case studies, and consequently did not have a placebo-controlled arm of the experimental design. A reasonable limitation underlying this study is based on the utilisation of an unblinded diet treatment experimental design that could impart a bias on the study participants, as well as because of recent reports of placebo effects. Many studies on epilepsy were designed to evaluate for a positive response to therapy, which is defined as a ≥50 per cent reduction in seizures. 48 49 In one study which combines the results from three placebo-controlled trials, a large proportion of dogs with IE responded to placebo alone, with an approximately 30 per cent reduction in seizures following placebo administration. 48 However, the dogs in the placebo group were on conventional ASD therapy that could have affected the results and outcome. This placebo response has been attributed to the regression to the mean effect, the natural waxing and waning course of epilepsy over time, the likelihood for improved patient care during participation in the trial and investigator and participant bias. 48 The presence of the strong placebo effect found in that report suggests that results from non-blinded studies, particularly those that involve a small number of animals and short follow-up time should be interpreted with some caution. a. Any incorrect or inaccurate data entry, or for any faulty, erroneous or failed electronic data transmissions;

Formulated with MCTs and neurosupportive nutrients, clinically proven to help enhance canine brain function. Specially formulated to help support cognitive function in senior dogs. Could see visible results in 30 days. Containing MCTs - (medium chain triglycerides) Ketogenic diet providing an alternative source of energy for the brain. These anecdotal observations kindled the idea of looking closer at the effect of diet on dogs with epilepsy. Holger emphasised the importance of giving a consistent diet, which can be extremely difficult in a real world situation, because one of the effects of epilepsy drugs is to stimulate appetite and so these dogs will always be looking for food. Giving leftovers from human meals can further add to the challenge of looking after a pet with epilepsy because ingredients, such as high salt levels in many human foods, can interfere with how dogs process some of the AEDs. It is not just the amount of food that matters, the individual nutrients are also important. Wlaź, P., Socała, K., Nieoczym, D., Łuszczki, J. J., Zarnowska, I., Zarnowski, T., Czuczwar, S. J., Gasior, M. (2012). Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice. Neuropharmacology 62, 1882–1889. doi: 10.1016/j.neuropharm.2011 The diet Purina® Pro Plan® Veterinary Diets NC NeuroCare™ will be presented to veterinarians at The North American Veterinary Community annual conference in Orlando, Florida.

The Royal Veterinary College (RVC) is the UK's largest and longest established independent veterinary school and is a constituent College of the University of London. The RVC offers undergraduate, postgraduate and CPD programmes in veterinary medicine, veterinary nursing and biological sciences, being ranked in the top 10 universities nationally for biosciences degrees. It is currently the only veterinary school in the world to hold full accreditation from AVMA, EAEVE, RCVS and AVBC. A further limitation to this study is the incomplete collection of blood samples for ASD monitoring from all dogs at both prefeeding and postfeeding time point, leaving open the fact that the authors could not clearly demonstrate ASD concentrations in the blood remained unchanged in all dogs throughout the study period. However in a previous clinical assessment of feeding a diet containing MCT oil to epileptic dogs, ASD levels were measured. 27 The ASD treatment regimens of the dogs remained the same between the placebo and MCT diet phases. There were no significant changes in serum concentrations of phenobarbital (P=0.423) or KBr (P=0.300) between the placebo-standardised diet and MCT diet, respectively. Given that approximately 50 per cent (10 out of 21) of the dogs here showed no change in serum ASD level, and the prior findings by Law and others, the authors would expect ASD serum concentrations in the other dogs were not altered. A final limitation is that chloride content of the previous diets from the six pets receiving KBr treatment was not specifically measured before starting the trial to specifically assess if therapeutic levels would be altered. However, for consistency across the study and consistency to previous clinical trials, all ASD regimens for all dogs were to remain unchanged throughout the study. It is also important to note that Purina Pro Plan NC NeuroCare has a chloride level of 0.20 g/100 kcal. Although the authors do not have the information of the chloride level for the pretrial diets fed to the six dogs receiving KBr in the study, by estimating that maintenance diets may likely contain chloride levels around 0.13–0.22 g/100 kcal, but could be as low as the minimum requirement of 0.03 g/100 kcal (American Association of Feed Control Officials, 2018). Thus, the test diet is at the high end of that range and consequently would have justified a potential elevation in KBr but would have confounded any observed diet effect.