Lemsip Max Cold and Flu Blackcurrant Sachets, With Paracetamol, Pack Of 10 (Packaging May Vary)

Product Information

Sympathomimetic amines: concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of cardiovascular side effects. Immediate medical advice should be sought in the event of an overdose, even if the patient feels well because of the risk of delayed serious liver damage (see section 4.9). Tricyclic antidepressants (e.g. amitriptyline): may increase the risk of cardiovascular side effects with phenylephrine. Paracetamol: Paracetamol is absorbed rapidly and completely mainly from the small intestine producing peak plasma levels after 15-20 minutes following oral dosing. The product should not be used during pregnancy unless recommended by a healthcare professional (see section 4.6).

Monoamine oxidase inhibitors (including moclobemide) (MAOIs): Hypertensive interactions occur between sympathomimetic amines such as phenylephrine and monoamine oxidase inhibitors (see section 4.3). symptoms associated with the common cold and influenza, including relief of aches and pains, sore throat, headache, fatigue and The maximum daily dose of this product is equivalent to 23.7 % of the WHO recommended maximum daily intake for sodium.

Symptoms of paracetamol overdosage in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12-48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. Immediate medical advice should be sought in the event of an overdose, even if the patient feels well because of the risk of delayed serious liver damage Phenylephrine should be used with care in patients with closed angle glaucoma and prostatic enlargement. This medicinal product contains 128.71 mg sodium per dose, equivalent to 6.4 % of the WHO recommended maximum daily intake for sodium.

Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: http://www.medicines.org.uk/emc/medicine/28101 for Honey & Ginger, and https://www.medicines.org.uk/emc/medicine/23354 for Lemon.Antiemetics: The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by cholestyramine. It comes in a few different variations and has plenty of tablet alternatives if you do not want to have your medicine in a sachet form. Caffeine: Caffeine is absorbed readily from oral, rectal or parenteral administration, but absorption from the gastrointestinal tract may be erratic. There is little evidence of accumulation in any particular tissue. Caffeine passes readily into the central nervous system and into saliva. Concentrations have also been detected in breast milk. It is metabolised almost completely and is excreted in the urine as 1-methyluric acid, 1-methylxanthine and other metabolites, with only about 1% unchanged. The safety of this medicine during pregnancy and lactation has not been established but in view of a possible association of foetal abnormalities with first trimester exposure to phenylephrine, the use of the product during pregnancy should be avoided. In addition, because phenylephrine may reduce placental perfusion, the product should not be used in patients with a history of preeclampsia. The systemic availability is subject to first-pass metabolism and varies with dose between 70% and 90%. The drug is rapidly and widely distributed throughout the body and is eliminated from plasma with a T1 /2 of approximately 2 hours. The major metabolites are glucuronide and sulphate conjugates (>80%) which are excreted in urine.

LEMSIP MAX COLD & FLU CAPSULES: Each capsule contains Paracetamol 500 mg, Caffeine 25 mg Phenylephrine hydrochloride 6.1 mg

Due to its aspartame content this medicinal product should not be given to patients with phenylketonuria. Due to the presence of caffeine, the product should be taken with care in patients with a history of peptic ulcers. Sympathomimetic agents: Concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of hypertension and other cardiovascular side effects (see section 4.3).