Vitamin B3 Nicotinamide (Niacinamide) 500mg 180 Capsules (V) Vegan. No-Flush Niacinamide. Made in The UK by Health4All

Product Information

In supplements, niacinamide might be listed on the label in niacin equivalents (NE). 1 mg of niacinamide is the same as 1 mg NE. Niacinamide is found in many vitamin B complex supplements with other B vitamins. It's also used in many topical creams and gels. NAM inhibits the activity of PARPs, which function in recognizing and inducing repair of DNA strand breaks. Therefore, suppression of PARP activity raises reasonable concerns on loss of DNA integrity or enhanced sister chromatid exchange (SCE) [ 98], which may causatively be associated with certain types of cancers [ 99]. For this reason, the carcinogenic and co-carcinogenic effects of NAM have been the focus of early studies. However, results in large ar Surjana D, Halliday GM, Damian DL. Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin. Carcinogenesis 2013; 34: 1144–9. DOI: 10.1093/carcin/bgt017. PubMed Thompson BC, Surjana D, Halliday GM, et al. Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in primary melanocytes. Exp Dermatol. Jul 2014;23(7):509-511. Cabrera-Rode E, Molina G, Arranz C, Vera M, et al. Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes. Autoimmunity. 2006;39(4):333-40. View abstract.

Vitamin B3 Nicotinamide (Niacinamide) 500mg | Health4All Vitamin B3 Nicotinamide (Niacinamide) 500mg | Health4All

Hussain S, Singh A, Alshammari TM, et al. Nicotinamide therapy in dialysis patients: a systematic review of randomized controlled trials. Saudi J Kidney Dis Transpl. 2020;31(5):883-897. doi:10.4103/1319-2442.301195. Damian DL, Patterson CRS, Stapelberg M, Park J, Barnetson RS, Halliday GM. UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide. J Invest Dermatol 2008; 128: 447–454. PubMed Safety considerations: Rash, stomach upset, elevated liver enzymes (at more than 3 grams (g) per day, though this is rare), thrombocytopenia (in people who have renal disease and are on dialysis). Minocha R, Martin AJ, Chen AC, et al. A Reduction in Inflammatory Macrophages May Contribute to Skin Cancer Chemoprevention by Nicotinamide. J Invest Dermatol. Feb 2019;139(2):467-469.

Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your needs. Pregnancy and breastfeeding: Niacinamide is generally acceptable in pregnant or breastfeeding people. However, it's always best to talk with your healthcare provider before starting a new supplement if pregnant or breastfeeding.

NIACINAMIDE - Uses, Side Effects, and More - WebMD

Ketteler M, Wiecek A, Rosenkranz AR, et al. Efficacy and Safety of a Novel Nicotinamide Modified-Release Formulation in the Treatment of Refractory Hyperphosphatemia in Patients Receiving Hemodialysis-A Randomized Clinical Trial. Kidney Int Rep 2020;6(3):594-604. View abstract. Niacinamide and nicotinic acid (aka niacin) are common forms of vitamin B3 in supplements. Your body can convert tryptophan from food into niacinamide as needed, and it may make niacinamide from niacin to an extent when there's enough of it. Navarrete-Solís J, Castanedo-Cázares JP, Torres-Álvarez B, et al. A double-blind, randomized clinical trial of niacinamide 4% versus hydroquinone 4% in the treatment of melasma. Dermatol Res Pract. 2011;2011:379173.

Elliott RB, Pilcher CC, Fergusson DM, Stewart AW. A population based strategy to prevent insulin-dependent diabetes using nicotinamide. J Pediatr Endocrinol Metab 1996;9:501-9. View abstract. Surjana D, Halliday GM, Martin AJ, Moloney FJ, Damian DL. Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials. J Invest Dermatol 2012; 132: 1497–500. Journal. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Kalasho BD, Minokadeh A, Zhang-Nunes S, et al. Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study. J Cosmet Sci. 2020 Sep/Oct;71(5):263-290.

Nicotinamide | DermNet Nicotinamide | DermNet

The clinical signs and symptoms of rosacea include increased facial skin dryness, redness and sensitivity. In at least two studies, moisturisers containing nicotinamide have been shown to improve skin barrier function in rosacea patients, leading to diminished reaction to irritants including cleansers and cosmetics. Anti-ageing skin care Bourgeois BF, Dodson WE, Ferrendelli JA. Interactions between primidone, carbamazepine, and nicotinamide. Neurology. Oct 1982;32(10):1122-1126. It is reported to improve complexion, by improving the pigmentation, blotchiness and redness of ageing skin; it is used in some cosmeceutical products. Kozan A, Guner RY, Akyol M. A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris. Dermatol Ther. 2020 Jul;33(4):e13534.Drago F, Ciccarese G, Cogorno L, et al. Prevention of non-melanoma skin cancers with nicotinamide in transplant recipients: a case-control study. Eur J Dermatol. Aug 1 2017;27(4):382-385. Monfrecola G, Gaudiello F, Cirillo T, et al. Nicotinamide downregulates gene expression of interleukin-6, interleukin-10, monocyte chemoattractant protein-1, and tumour necrosis factor-alpha gene expression in HaCaT keratinocytes after ultraviolet B irradiation. Clin Exp Dermatol. Mar 2013;38(2):185-188. Omidian M, Khazanee A, Yaghoobi R, Ghorbani AR, Pazyar N, Beladimousavi SS, Ghadimi M, Mohebbipour A, Feily A. Therapeutic effect of oral nicotinamide on refractory uremic pruritus: a randomized, double-blind study. Saudi J Kidney Dis Transpl. 2013 Sep;24(5):995-9. View abstract.