The Breakers Series: Books 1-3

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On March 22, 2021, Isaacson appeared on The Late Show with Stephen Colbert to discuss the book. [3] Reception [ edit ] November 17 – December 30, 2023 Admission at 4 pm, 4:30 pm, 5 pm, 5:30 pm and 6 pm. Gates close at 6:30 pm. House & grounds close at 8 pm This was a buddy read with my friend Marialyce, and while we both had reservations with the way the story was told, it inspired many thoughtful discussions. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned ​a curiosity ​of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.

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You need to at least like science or be interested in science a little bit to truly appreciate what Isaacson has done here, but I was impressed with his ability to tell this complicated story. Subsequently, Feng Zhang (a guy) nearly made off with all the cash and prizes and in doing so, nearly stole the historical spotlight from Charpentier and Doudna (both women).

Even though much has changed since the 1960’s, women in science still experience HUGE institutional sexism. Witches and vampires, angels and princesses, skeletons and superheroes, get ready! There’s big Halloween fun for the family at Newport’s biggest mansion. I've taken it from five stars to four after mulling the book and having written the review, I realize I only want to give it three. This is a good book but too wide in scope. It's not a biography of Jennifer Doudna, although there is a focus on her. The camaraderie in the lab was not an accident: in hiring, Doudna placed as much emphasis on making sure someone was a good fit as she did assessing their research accomplishments.'

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This all started in 2012 when Emmanuelle Charpentier and Jennifer Doudna dropped a seminal (no pun intended) paper on CRISPR Cas9. Very interesting too to learn that lots of animal breeders, cattle farmers, etc are using CRISPR and see lot's of opportunities to use it more. In 2019 a Chinese national scientist named He Jiankui conducted a germline editing process on (x3) embryos, essentially birthing the world's first gene-edited babies. We invite you to become a member of the Preservation Society today. In addition to joining an active community of preservation supporters and advocates, members are offered unlimited access to all open houses. CRISPR and gene editing are barely getting started. Most of us will spend countless hours in coming years and decades following this science's developments. One should expect more books on genetic science than any other subjects singing peans of its impact on our health and life. It is not an exaggeration to suppose that genetic sciences' influence could be more than any other scientific revolutions so far. If the field offers equally exciting and inspirational stories of the professionals involved, like Doudna, Charpentier, and others in the book, it is even better.

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The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Apparently, when a virus infects a bacteria, it inserts a little RNA =>DNA sequence into the host cell. Well, what can I say about this book? I am feeling intensely emotioanl about this one and obviously, I would give it A Thousand Stars! Apart from Atul Gawande's "Being Mortal", this is another best-read for me in 2021! Such a brilliant, marvellous piece on CRISPR, its application in genome editing, diagnosing & curing diseases, and how it can be used to fight coronavirus. And most importantly, the star of this book is Jennifer Doudna - the Wonder Woman in science. As sad as those days were for her, their groundbreaking findings were the catalyst to Doudna and her colleagues putting in place the tools that could edit genes. During a TV interview for a science news show, when explaining what the implications of such technology could be, she said, "One possibility is that we might be able to cure or treat people who have genetic defects." Largely by being adroit at operating within the patent system and due to being well funded and supported in his enterprises.

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The research is still ongoing and very much alive. This technology is promising us A Brave New World of genetic editing. It’s both captivating and terrifying for its multifaceted possibilities. By limiting gene edits to those that are truly "medically necessary," she says, we can make it less likely that parents could seek to "enhance" their children, which she feels is morally and socially wrong.' It's hard to imagine how a gene supermarket, with price points only affordable to the already rich and privileged, would result in anything other than a super-elite class. Those unable to keep up would merely be serfs whose only existence would be to serve the master class. Bio-techno-feudalism, as it were. That is not the world I want to live in. CRISPR-Cas9 systems can be ‘programmed’ relatively easily and inexpensively, to conduct ‘germline editing’ (i.e. insertion of designer DNA, or deletion of unwanted DNA) into the organism’s genetic code.The Infinites don’t want to help but, if they don’t, there is a risk that their own identities will be made public, which would have devastating consequences. And so begins a dizzying and disorientating adventure that has them zigzagging across time, from 2050 to the Victorian great railway age. I'm giving this five stars because a) Isaacson maintained my interest throughout on a pretty complex and confusing topic and b) the research and c) so timely. My level of interest and enjoyment was more around a 3 1/2 star, but that had nothing to do with the quality of the book. This is an extremely rich text about a recent scientific advance that has already changed a lot, and will probably end up changing everything.