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The study also reveals just how effective these appetite-reducing properties are in helping individuals lose weight at a consistent, healthy rate. Subjects were instructed to maintain a nutritionally balanced hypocaloric diet according to the individual’s energy requirement. Obesity was also found to increase the risk of depression caused by disparagement of body image and negative emotional reaction to dieting [ 5], leading to job absenteeism, lowering productivity, and driving healthcare costs [ 6, 7]. Litramine has undergone multiple human clinical trials, including a 14-week trial focused on weight loss and a 24-week weight maintenance study. In our study, the overall tolerability towards the IQP-AE-103 in high and low doses was comparable to that in the placebo, according to the rating by the subjects and the investigator.
Weight management treatments range from natural, oral solutions to risky, invasive surgical procedures. When uploading your files to PDF2Go, you can be sure that your files are handled securely and discrete.
InQpharm’s proprietary complex Litramine has its origins in Opuntia ficus-indica, a cactus also known as “prickly pear.
Moreover, appetite sensations in the study were assessed using VAS and rating scales, which were not validated for the specific use to measure changes in a similar study design. The evaluation of the efficacy of IQP-AE-103 was based on the null hypothesis that there are no statistical differences between IQP-AE-103 and placebo in mean reduction of body weight after 12 weeks of treatment. In consideration of the nonparametric test procedure, the necessary sample size was equal to 28 subjects per study arm. In summary, the study results provide the first promising evidence that the intake of IQP-AE-103 causes weight loss in overweight and moderately obese subjects in conjunction with a mild hypocaloric diet. Current solutions include Litramine, which was awarded the first Class II medical device certification for a plant-based weight management product in the world, and Tanitol, the first enzyme inhibitor that achieved medical device certification by targeting multiple digestive enzymes.
Blaut, “Effects of inulin and lactose on faecal microflora, microbial activity, and bowel habit in elderly constipated persons,” American Journal of Clinical Nutrition, vol. Dehydrated okra powder was obtained from whole okra pods ( Abelmoschus esculentus) that were cleaned, sliced, oven-dried at 60°C, and milled to form a fine powder. Additionally, okra pods contain dietary fibre and proteins [ 23], which may play a role in fat binding, thus decreasing absorption of dietary fat and consequently leading to body weight reduction [ 24]. Changes in gut microbiota composition occur with age [ 52], and it has been shown that altered gut microbiota may be associated with obesity [ 53], since IQP-AE-103 contains fibres and polysaccharides from okra pod and inulin, it is likely that the composition of the intestinal gut microbiota may be positively influenced by the consumption of IQP-AE-103.
in the high-dose IQP-AE-103 group, a proportion that is significantly higher than that in the low-dose and the placebo groups.In the next step, the weight loss and weight maintenance efficacy of IQP-AE-103 should be evaluated in longer clinical trials. Increases in waist circumference and weight as predictors of type 2 diabetes in individuals with impaired fasting glucose: influence of baseline BMI: data from the DESIR study,” Diabetes Care, vol. The overall compliance (%) was defined as (the total number of capsules taken divided by the total number of capsules to be taken) multiplied by 100. In our study, BMI, body fat mass, and waist and hip circumference were also found to be decreased significantly in both IQP-AE-103 dose groups.