N / C 100 5ml needleless plastic syringes, can be used multiple times, suitable for scientific laboratory, metering, watering, adding water, refueling

Product Information

shows the improved footprint achieved when this device was operated at conditions corresponding to those of FIG. comprises an elongate tubular converging-diverging nozzle having a rupturable membrane initially closing the passage through the nozzle and arranged substantially adjacent to the upstream end of the nozzle. The nozzle 2 bounds the gas flow path, that is to say it surrounds and defines the space through which the gas may flow. the particles are still drawn into the gas flow path because the pressure is at least reduced compared to the pressure to which the particles are exposed (i. When used with a payload of 1 mg of polystyrene spheres, it produced a crater in the centre of the 3% agar gel target.

the right-hand end (as drawn) of the gas cylinder 44 is provided with a longitudinally extending nose 49 , which nose is capable of being fractured, so as to allow the escape of gas from the interior of the cylinder 44 , upon the application of lateral pressure to the nose 45 in the direction identified by the arrow referenced 46 . Where the nozzle has a divergent downstream section, it has been found that by extending the length of the nozzle to increase the diameter of the nozzle at its downstream exit, significantly larger target areas on the skin or mucosa may be penetrated by the particles, with good uniformity of distribution across the larger target area. mm for the first and second convergences respectively, equating to flow cross-sectional area ratios of 1:6. If you have what feels like razor bumps or acne on the back of your neck or scalp, you may have acne keloidalis nuchae. A61M2005/005— Magazines with multiple ampoules directly inserted into an injection or infusion device, e.

The term therefore encompasses those compounds or chemicals traditionally regarded as drugs, vaccines, and biopharmaceuticals including molecules such as proteins, peptides, hormones, biological response modifiers, nucleic acids, gene constructs and the like. mm diameter sonic throat and a 3 mm diameter upstream exit nozzle parallel section and using a 5 ml, 40 bar helium cannister gave the footprint and penetration results shown in FIG. By distributing the particles in the flow of gas from a needleless syringe using the method of the above first aspect of the present invention, whilst the nozzle's downstream exit is positioned adjacent a target area of skin or mucosa, the particles may be administered to the skin or mucosa. is a top plan view of the target area of the gel target, a side cross-sectional view through the gel target and a graph showing the penetration depth variation with position after the firing at the gel target of particles from the needleless syringe shown in FIG.

However, the gas issuing from the device is actually a mixture of helium and air, due to the air that is drawn in along with the particles via the particle inlet passage 10. a sonic nozzle 41 Provided at the upstream end of the particle entrainment chamber 39 is a sonic nozzle 41 , whose central aperture forms the first convergence or constriction 42 to the flow of gas from the gas source. This reduced pressure can then be used to draw in a payload of particles from the particle source 11 (not shown in FIG. the left hand image shows the footprint (approximately 11 mm diameter) of the particles and a 3% agar gel target: there is an increased concentration of particles near the centre of the footprint, but the asymmetry of the distribution is not so noticeable in this image.the present invention is primarily concerned with the reduction of noise and improved uniform particle spread that can be achieved by using the Venturi effect to draw the particles into the gas flow path.

the particles may be initially lightly adhered to the inside of a tubular member which is initially provided in the gas flow path. Jean Sales-Girons invention, Appareil pour l'aquapuncture to l'Académie Impériale de Médecine in Paris. the seventh embodiment relates to a construction in which the particles are provided in fluid communication with an upstream portion of the gas flow path such that, in use, the reduced pressure need not be sub-atmospheric and need only be reduced compared to the pressure at that upstream portion of the flow path.It must be noted that, as used in this specification and the appended claims, the singular forms “a”, “an” and “the” include plural referents unless the context clearly dictates otherwise.

and it has been found that the transsonic gas jet formed effectively entrains the particles such that they are uniformly distributed in the gas flow. shows a fourth embodiment of needleless syringe in accordance with the present invention in which the chamber 8 has been replaced by a divergent section 60 . If the particle inlet passage 10 is in communication with a portion of the particle entrainment chamber 8 that is at atmospheric pressure or higher, particles will not be drawn into the particle entrainment chamber 8 when the syringe is fired, assuming the particle source is at atmospheric pressure.Before describing the present invention in detail, it is to be understood that this invention is not limited to particular pharmaceutical formulations or process parameters as such may, of course, vary. Any of the already described nozzles may be contoured, for example, using the method of characteristics, to provide a reduction in the number of oblique shock waves that form in the nozzle during use. These particles have a lower density than either polystyrene or lidocaine and consequently they do not penetrate as deeply for a given velocity.